Canadian researchers from the Université de Montréal and the University of Alberta have found a protein in the progression of breast cancer. Their study, published in the Journal of Biological Chemistry, finds that the protein ARF1 plays a major role in cancer cell growth and the spread of tumors.
Dr. Claing and her colleagues used invasive breast cancer cell lines to study ARF1's role. When ARF1 activity was chemically blocked in the study, breast cancer cell migration and growth was slowed down. Conversely, when ARF1 was overproduced in these cells, their movement was enhanced.
This ARF1 protein could become a therapeutic target for the treatment of invasive breast cancers.